What are the precautions for colistimethate (Coly-Mycin M Parenteral)?

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Colistimethate (Coly-Mycin M Parenteral) has precautions that your doctor should discuss with you. These include:

  • Do not use colistimethate if you know you are allergic to it or any other medication in the class of polymyxin antibiotics.
  • Make sure you tell your doctor and pharmacist every nonprescription substances you are taking, including vitamins, aspirin or any dietary supplements, including any prescription drugs you are taking. Colistimethate may interact with other antibiotics, such as amikacin (Amikin), cephalothin, gentamicin (Garamycin), netilmicin (Netromycin), tobramycin (Nebcin), amphotericin B (Fungizone), capreomycin (Capastat), polymyxin B (Aerosporin) and vancomycin (Vancocin). It may also interact with succinylcholine and tubocurarine.
  • Make sure you tell your doctor if you have kidney problems or the neurological condition myasthenia gravis.
  • Make sure you tell your doctor about your plans to get pregnant, if you are currently pregnant or if you are breastfeeding. Colistimethate might cause harm to a developing baby.
  • Colistimethate may cause drowsiness.
  • If colistimethate is not properly used, it may cause muscle weakness and difficulty breathing.