Are there any risks in taking Zosyn (piperacillin and tazobactam)?

Stacy Wiegman, PharmD

Pharmacy

Yes. The risks of taking Zosyn (piperacillin-tazobactam) include allergic reactions which are potentially life-threatening. The doctor needs to know about all previous allergic reactions to any type of penicillin medication. Zosyn can also trigger severe attacks of diarrhea. If the diarrhea has blood in it, the doctor should be told immediately. Over-the-counter anti-diarrhea medications should not be taken until the doctor has evaluated the situation. Zosyn can cause severe skin reactions; be sure to tell a healthcare provider if you develop a rash after receiving Zosyn. Since Zosyn is injected intravenously, the following symptoms around the injection site can occur: redness, warmth, tenderness, irritation, pain, swelling or fluid drainage.

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