What should I know about trimethoprim before taking it?

Before taking trimethoprim you should be aware of some of the risks associated with this medication. Trimethoprim may cause complications if taken for a prolonged period of time. Complications may include a severe intestinal condition called pseudomembranous colitis, oral or vaginal yeast infection or other types of infections. To reduce your risk, only use trimethoprim for the length of time directed by your doctor and talk to your doctor if you develop any new symptoms of infection, diarrhea and stomach pain or cramping. People with certain medical conditions shouldn't take trimethoprim. If you're allergic to any ingredients in trimethoprim, don't take this medication. If you have anemia caused by low folate blood levels, you shouldn't take trimethoprim. Before taking trimethoprim, tell your doctor your medical history, especially if you have kidney or liver problems, vitamin deficiencies, diabetes or blood problems such as porphyria.

Trimethoprim may harm a fetus, so pregnant women should take this medication only if absolutely necessary. Trimethoprim also passes into breast milk, so if you are taking this medication talk to your doctor before breastfeeding. Some medications also may interact with trimethoprim. Tell your doctor if you're taking dofetilide, cyclosporine, phenytoin, sulfones, methotrexate, digoxin, angiotensin-converting enzyme (ACE) inhibitors, angiotensin-receptor blockers (ARBs) or certain diuretics. Other medications not listed here also may interact with trimethoprim. Make sure to discuss with your doctor all of the medications and supplements that you are taking, before taking trimethoprim. If you have questions about any of the risks associated with trimethoprim, talk to your doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.