Who should not use adapalene gel?

Adapalene gel has not been approved for use in children younger than 12 years of age. Anyone with skin conditions, such as psoriasis or cancer, should let their doctor determine if adapalene is appropriate for them. Pregnant women should generally avoid using adapalene. This medication is an FDA pregnancy Category C, meaning that it may cause harm to the fetus. Anyone who is allergic to any ingredient in adapalene lotion shouldn't use this medication.