Does taking oral isotretinoin affect liver function?

Dr. Doris Day, MD
Because oral isotretinoin is metabolized or digested by the liver, as is alcohol, you should try to avoid drinking alcohol while on oral isotretinoin therapy. There have been reports of liver function abnormalities that may have been related to the drug, most of which improved with either continued administration of the drug or after the medication was stopped. The published reports have been nearly unanimous in showing the lack of isotretinoin-induced liver damage of any kind. However, regular blood tests are still routinely done to ensure normal liver-function values.
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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.