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Is there a difference between adapalene gel and adapalene lotion?

Yes. Adapalene gel and adapalene lotion are both topical acne treatments that contain the same retinoid-type active ingredient. Each uses a different substance to carry the medication. One is a gel, one is a lotion, and there is a third which is a cream. The difference is that only the gel is available in two concentrations of adapalene (0.1 percent and 0.3 percent). The lotion and the cream are available in one concentration (0.1 percent). The adapalene 0.1 percent cream and gel are sold under the brand name Differin and the generic name. The 0.3 percent gel and the 0.1 percent lotion are sold under the brand name Differin only. Whether you are prescribed the cream or the gel, you will apply it in the same way. You will be warned about the same possible side effects.
 

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