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Who should not take primaquine?

Primaquine should not be used by those who have glucose-6-phosphate-dehydrogenase deficiency. These individuals have a higher risk of developing hemolytic anemia. If you have a history of allergic reactions to primaquine or if you are currently taking quinacrine, you may not be able to take this medication. Also, people who have lupus or rheumatoid arthritis may be unable to take this medication. Pregnant women and people over the age of 65 should not use primaquine except under the close supervision of their physician.