Who should not take isoniazid, pyrazinamide, and rifampin?

Do not take isoniazid-pyrazinamide-rifampin (Rifater), a combination drug used to treat tuberculosis (TB), if you have the following: severe liver disease; gout or other painful joint conditions; serious side effects from past use of isoniazid, including arthritis, fever or chills; medication-induced hepatitis; an allergy or sensitivity to any of the drug's ingredients. You also should not take isoniazid-pyrazinamide-rifampin with the following medications: lapatinib or other tyrosine kinase receptor inhibitors; ranolazine; temsirolimus; and voriconazole. If you need one of these medications, you and your doctor must decide which disease needs to be treated first (probably the TB) and which to postpone.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.