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What are side effects of isoniazid, pyrazinamide and rifampin?

Side effects of isoniazid-pyrazinamide-rifampin (Rifater), a combination antibiotic prescribed to treat tuberculosis (TB), range from mild to serious. Get immediate medical help if you notice any of these side effects: diarrhea; nausea; vomiting; lack of appetite; yellowed eyes or skin; urine that is dark, scant or absent or painful or difficult to pass; feeling exhausted or overly weak; breathing problems; rapid, fluttering heartbeat; bleeding or bruises that are unusual; headaches; chest pain or tightness; pain in the digestive tract, bones, muscles or joints; swelling in the joints; gout that gets worse; tingling or numb legs, feet or hands; sore throat; cough, including coughing up blood; fever or chills; itching, rash or hives; blurry vision; feeling anxious, confused or behaving oddly; seizure; hepatitis; diabetic coma; symptoms of an allergic reaction, such as hives, breathing problems, closing of the throat or swollen face, tongue or lips. Mild side effects include: minor weakness, fatigue, and urine, feces, saliva, sweat and tears that are stained reddish-orange. Isoniazid-pyrazinamide-rifampin may cause other side effects. Ask your doctor for advice about any side effects.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.