What are side effects of isoniazid, pyrazinamide and rifampin?

Side effects of isoniazid-pyrazinamide-rifampin (Rifater), a combination antibiotic prescribed to treat tuberculosis (TB), range from mild to serious. Get immediate medical help if you notice any of these side effects: diarrhea; nausea; vomiting; lack of appetite; yellowed eyes or skin; urine that is dark, scant or absent or painful or difficult to pass; feeling exhausted or overly weak; breathing problems; rapid, fluttering heartbeat; bleeding or bruises that are unusual; headaches; chest pain or tightness; pain in the digestive tract, bones, muscles or joints; swelling in the joints; gout that gets worse; tingling or numb legs, feet or hands; sore throat; cough, including coughing up blood; fever or chills; itching, rash or hives; blurry vision; feeling anxious, confused or behaving oddly; seizure; hepatitis; diabetic coma; symptoms of an allergic reaction, such as hives, breathing problems, closing of the throat or swollen face, tongue or lips. Mild side effects include: minor weakness, fatigue, and urine, feces, saliva, sweat and tears that are stained reddish-orange. Isoniazid-pyrazinamide-rifampin may cause other side effects. Ask your doctor for advice about any side effects.