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What are the side effects of sulfadoxine and pyrimethamine?

Side effects related to the use of sulfadoxine and pyrimethamine range from mild to severe. Milder side effects include: drowsiness, headaches, nervousness, diarrhea, joint pain and anxiety. More severe side effects include: tongue irritation, rash, sensitivity to sunlight, yellow eyes and skin, fever, vomiting, weakness, fatigue, abnormal bleeding and bruising, swelling in upper belly, sores on mouth, bloody urine and feces, sore throat and mouth, difficult urination, blistering and loosening of skin, nausea, back pain, muscle cramps and pain, decreased appetite, chills, cough, chest pain and black, tarry stools. Some rare side effects that may occur include: changes in skin color on the face, trouble breathing, itching and burning skin, swelling of neck, constipation, swelling of eyelids and stomach pain. If you experience any of these severe side effects, or if any of your milder side effects worsen, you should speak with your doctor right away.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.