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Is isoniazid-rifampin safe for pregnant or breast-feeding women to take?

No, isoniazid-rifampin (Rifamate) is probably not safe to take during pregnancy. The doctor prescribing it must be informed about pregnancy status. Isoniazid-rifampin is assigned to pregnancy Category C, meaning that studies do not adequately show if it poses a risk to a fetus. If this drug is taken near the end of pregnancy, it can cause out-of-control bleeding in both mom and baby at birth. Your doctor also may advise you not to breastfeed if you take isoniazid-rifampin. This drug is passed through breast milk and may affect a nursing infant.

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