Does isoniazid-rifampin cause liver damage?

Yes, isoniazid-rifampin (Rifamate) can damage the liver and cause hepatitis, a potentially deadly disease. The risk for developing hepatitis while taking isoniazid-rifampin is related to age, alcohol abuse, injectable drug abuse, pre-existing liver disease and female gender (especially Hispanic, African-American or recently given birth). The doctor will regularly check to make sure the liver is functioning properly. Signs of liver problems can include: yellowed eyes or skin; dark urine; nausea; vomiting; no appetite; painful or tender stomach; tingling or numb feet or hands; and feeling weak, exhausted or generally unwell.