Do atovaquone and proguanil interact with other substances?

Yes, atovaquone-proguanil may interact with other medications. These include: rifampin, tetracycline, metoclopramide, rifabutin and blood thinners, such as warfarin. Interactions may increase, decrease or change the effects of the medications. In general, make sure that your doctor is aware of all the medications that you are taking, or intend to take, while you are taking atovaquone-proguanil.