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What are the side effects of lopinavir and ritonavir (LPV/r)?

Common side effects of lopinavir-ritonavir (LPV/r) include: diarrhea, heartburn, insomnia, headaches, rash, weakness, abdominal pain, nausea, vomiting, missed menstrual periods, gas, loss of appetite, numbness, burning or tingling sensations, difficulty swallowing, chills, fever, decreased libido, low testosterone in men, muscle pain or hypertension. Rare side effects of lopinavir-ritonavir occur in less than two percent of those who take the drug. They include: sinus infection, eczema, vertigo, acne, asthma, ringing in the ears, confusion, dizziness, weight gain, anemia, constipation, varicose veins, dry mouth, back pain, migraines and hypothyroidism. Serious side effects of lopinavir-ritonavir are signs of a dangerous complication with the drug. Tell your doctor right away if you experience any of the following: swelling of the mouth or throat, difficulty breathing, wheezing, hives, rash, itching, irregular pulse or a sensation of irregular heart rhythm, lightheadedness, fainting, dizziness, unusual or excessive bleeding or bruising, hyperglycemia, or high blood sugar, changes in body fat distribution, high triglycerides or cholesterol, depression, general feelings of malaise, nausea, loss of appetite, yellowing of the skin and eyes (jaundice), pain in the upper right portion of the abdomen, pale stools, flushing, fatigue, dry mouth and increased urination.


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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.