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What should I know about tipranavir before taking it?

You should know that tipranavir (Aptivus) is used to treat human immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS). The tipranavir capsules should be swallowed whole and never crushed or chewed. Tipranavir should always be taken with food. Tipranavir should always be taken with ritonavir to make the blood levels of tipranavir higher. It is stored in the refrigerator before dispensing but may be stored at room temperature by the patient. It must be used within two months after opening the bottle. Try not to run out of tipranavir and ritonavir, because your virus levels will increase if these medications are not taken daily.

There are a few risks when taking tipranavir and ritonavir together. Bleeding in the brain, although this is rare, may occur, as well as severe liver disease, and both of these conditions could lead to death. Stop taking these medications and call your doctor right away if you experience dark urine, light colored stools, yellow skin or eyes, nausea, no appetite, unusual tiredness, pain under your right ribs, bleeding, bruising or unusual mood swings. Medications that should be avoided while taking tipranavir include: midazolam, amiodarone, astemizole, bepridil,  quinidine, pimozide, flecainide, ergot alkaloids (migraine medication), propafenone, terfenadine and triazolam, because they could cause serious or life-threatening reactions. Caffeine, warfarin (Coumadin), omeprazole (Prilosec), digoxin and dextromethorphan could affect how tipranavir works. Make sure your doctor knows about any other medications and supplements you take, especially birth control pills.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.