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Is it safe to take lamivudine and zidovudine while I am pregnant?

Lamivudine-zidovudine may not be safe to take when you are pregnant. It has been classified as a pregnancy Category C drug by the United States Food and Drug Administration. The lamivudine-zidovudine combination drug has not been studied fully in animals or humans, but zidovudine has been studied in humans and both drugs alone have been studied in animals. Lamivudine increases the risk of miscarriage in rabbits, but not rats. Zidovudine increases the risk of miscarriage and birth defects in rats, but the birth defects are only seen with very high doses. Studies of zidovudine during pregnancy in humans have generally shown no problems. In fact, zidovudine is currently approved for use in pregnancy to reduce the risk of the human immunodeficiency virus being transferred to the fetus. Therefore, if you take lamivudine-zidovudine during pregnancy, there may be a small risk to the developing fetus, but this should be weighed against the risk of other treatment and the potential beneficial effects of the drug to you and your baby.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.