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How does lopinavir and ritonavir (LPV/r) interact with drugs and food?

Lopinavir and ritonavir (LPV/r) interacts with a number of other drugs. When used with any of the following medications, LPV/r can increase or decrease levels of those medications in your blood, which raises your risk of serious side effects and can make your medications less effective. Talk to your doctor before taking lopinavir and ritonavir (LPV/r) if you are taking any of the following: arrhythmia medications, chemotherapy drugs, colchicines, alfuzosin, bosentan, amlodipine, felodipine, diltiazem, isradipine, verapamil, nifedipine, nicardipine, nisoldipine, nimodipine, rifabutin, itraconazole, clarithromycin, ketoconazole, voriconazole, colchicines, nilotinib, vinblastine, dasatinib, vincristine, delavirdine, bupropion, atovaquone, dexamethasone, fentanyl, fluticasone, maraviroc, nevirapine, methadone, salmeterol, phenytoin, tenofovir, trazodone, sirolimus, cyclosporine, tacrolimus, amprenavir, tipranavir, nelfinavir, indinavir, fosamprenavir, saquinavir, atazanavir, darunavir, simeprevir, vardenafil, sildenafil, tadalafil, hormonal birth control, rosuvastatin, atorvastatin, delavirdine, efavirenz, rifampin, seizure medications, St. John's Wort, bromocriptine, ergonovine, dihydroergotamine, methylergonovine, lovastatin, simvastatin, midazolam, triazolam, quetiapine and pimozide.
Taking lopinavir and ritonavir with some calcium channel blockers, digoxin or atazanavir can increase your risk of a dangerous arrhythmia known as heart block. Combining lopinavir and ritonavir with QT-prolonging medications can increase your risk of QT prolongation, a dangerous arrhythmia. Lopinavir and ritonavir is available in a liquid solution, which contains alcohol. The liquid solution should not be combined with disulfiram or metronidazole, since these medications must not be mixed with alcohol. Lopinavir and ritonavir (LPV/r) currently has no known food reactions. You may continue your normal diet unless your doctor tells you otherwise.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.