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Does lamivudine, nevirapine and zidovudine interact with other drugs?

Since LNZ (lamivudine, nevirapine and zidovudine) is a combination of three drugs, there could be many other drugs that interact with LNZ. Other antiretroviral regimens that include any of same medications as LNZ  should not be added to LNZ. For example, lamivudine should not be taken with any other combination that already includes lamivudine. It is very important that you make sure your doctor knows all of the medications you are taking, particularly if you are switching regimens. The combination of lamivudine and zidovudine has been shown to interact with sulfamethoxazole, trimethoprim and zalcitabine.

LNZ should be avoided or monitored closely when used with dapsone, didanosine, IV pentamidine, isoniazid, sulfonamides and alcohol. Zidovudine and stavudine should not be used together in HIV treatment. Other drugs that may cause interactions when used with zidovudine include the following: acetaminophen, aspirin, atovaquone, benzodiazepines, cimetidine, clarithromycin, doxorubicin, fluconazole, ganciclovir, indomethacin, interferon-alpha, methadone, morphine, phenytoin, probenecid, ribavirin, rifampin, sulfonamides and valproic acid. Additionally, radiation therapy, cytotoxic agents or medications that could cause blood dyscrasias should be avoided.

Nevirapine may interact with the following drugs and dose adjustments may be required in some cases: enteric-coated didanosine, ketoconazole, methadone, prednisone, protease inhibitors, rifabutin, rifampin, St. John's Wort and tenofovir disoproxil fumarate. Birth control pills with norethindrone or ethinyl estradiol should not be the only method of contraception as there could be some issues when used with nevirapine. Be sure to talk to your doctor about everything that you take before starting the LNZ combination treatment. Vitamins and herbal supplements could interact with any of the drugs. All three may be taken with or without food.