Are there any risks in taking lamivudine/zidovudine?

The risk for side effects from taking lamivudine-zidovudine, for which black box warnings have been issued include: bone marrow toxicity with low white and red blood cell counts; muscle problems; high lactic acid levels; liver disease; and worsening of hepatitis B infection. Other side effects include: inflammation of the pancreas; depression; low platelet counts; redistribution of body fat; allergic reactions; seizures; headaches; fatigue; nausea; vomiting; diarrhea; nasal symptoms; cough; insomnia; nerve problems; bone pain; muscle pain; fever; chills; heartburn; stomach pain or cramps; joint pain; dizziness; decreased appetite; and loss of hair. Lamivudine-zidovudine may be associated with an increased risk of damage to a developing fetus if it is used by a pregnant woman. There also is a risk of passing the medication to a nursing child, if lamivudine-zidovudine is taken while breastfeeding.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.