How does hydrocortisone interact with other medications?

Prescription hydrocortisone can interact with other medications. It's important to tell your doctor about any medication (prescription or over-the-counter), supplement, vitamin, or herbal therapy you are using, before using hydrocortisone. Make sure to discuss: arthritis medications, aspirin, blood thinners, cyclosporine, digoxin, estrogen, ketoconazole, oral contraceptives, phenobarbital, phenytoin, theophylline, vitamins, and diuretics (water pills).

The following medications can decrease the effectiveness of hydrocortisone medication: barbiturates, carbamazepine, hydantoins, live vaccines, mifepristone, and rifampin.

The following medications can cause severe hydrocortisone side effects if used at the same time as hydrocortisone: azole antifungals, clarithromycin, methotrexate, steroidal contraceptives, troleandomycin, ritodrine, and warfarin.

Because even vitamins or common over-the-counter medications such as aspirin can interact with hydrocortisone, do not begin any new medication or supplement without first talking to your doctor. Remember to discuss any allergy you have to medication, foods, and dyes. Hydrocortisone tablets or capsule may contain other ingredients that could trigger an allergic reaction.

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