What interactions are common for bupivacaine HCI and epinephrine injection?

Bupivacaine-epinephrine injection should not be combined with monoamine oxidase inhibitors or tricyclic antidepressants as this can lead to severe and ongoing hypertension (high blood pressure). In addition, dangerously irregular heartbeats may occur if this injection is used in someone who is -- or was recently -- on chloroform, halothane, cyclopropane, trichloroethylene or similar anesthetics. If sedatives are being used to reduce anxiety during a medical procedure, a reduced dose of bupivacaine-epinephrine injection should be given to avoid the addictive effect of this combination.

Continue Learning about Anesthetic Agent

What should I know before using topical lidocaine?
Donna Hill Howes, RNDonna Hill Howes, RN
If you have heart conduction disorder (AV block) or impaired liver function, lidocaine may not be a ...
More Answers
What medications interact with benzodiazepines?
Dr. John Preston, PsyDDr. John Preston, PsyD
When taking benzodiazepines, any other type of medication that causes drowsiness or impaired alertne...
More Answers
What is conscious sedation?
American Society of AnesthesiologistsAmerican Society of Anesthesiologists
Once referred to as "twilight sleep," the term "conscious sedation" (more appropriately called "seda...
More Answers
What is an anesthetic?
Piedmont Heart InstitutePiedmont Heart Institute
An anesthetic is a drug or other substance that causes a loss of feeling or awareness. Local anesthe...
More Answers

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.