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Why does Zydone have a warning?

The warning on containers of the prescription pain reliever Zydone (hydrocodone and acetaminophen) is required by the Food and Drug Administration. The warning says: "Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 milligrams per day, and often involve more than one acetaminophen containing product."

Each Zydone tablet contains 400 milligrams, or one-tenth the amount described in the warning. To minimize your risk of liver damage while taking Zydone, do not take any other medication that contains acetaminophen. Read labels carefully; acetaminophen is contained in many over-the-counter products, including medications to treat colds, flu, headaches and menstrual symptoms. To protect your liver, you should also avoid alcohol while you're on Zydone.

Take Zydone exactly as your doctor tells you to. Do not take a higher dose or take it more frequently or for a longer period of time than your doctor recommends.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.