Who should not take Zydone?

You should not take the prescription pain medication Zydone (hydrocodone and acetaminophen) if you've ever had an allergic reaction to the drug or to acetaminophen, hydrocodone or any other narcotic or opioid drug.

Zydone may not be recommended for the following people:
  • pregnant women
  • women who are breastfeeding
  • children
  • people with liver or kidney disease
  • people with underactive thyroid glands
  • people who have Addison's disease
  • men with enlarged prostate glands
  • people who have narrowing of the urethra
  • people with lung disease 
  • people who take certain other medications, including antidepressants, antihistamines, antianxiety or antipsychotic medications or other narcotic drugs or other drugs that contain acetaminophen 
  • people who drink alcohol and will not stop while taking Zydone
  • people who have been addicted to narcotics in the past
In addition, some people should be particularly cautious when they start Zydone:
  • People who have to drive or operate machinery should see how Zydone affects them before attempting these activities.
  • People ages 65 and older may need to start with a very low dose of Zydone.
Talk to your doctor and pharmacist for more information about Zydone and how to take it safely.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.