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Who should not take Synalgos-DC?

You should not take Synalgos-DC (dihydrocodeine, aspirin, caffeine) if you are allergic to or can't tolerate dihydrocodeine, aspirin or caffeine, the active ingredients in Synalgos-DC, or other opioid medications or nonsteroidal anti-inflammatory drugs (NSAIDs).

Also, if you've taken a monoamine oxidase (MAO) inhibitor (a type of drug most often used to treat depression) within the past 14 days, you should not take Synalgos-DC. Women who are breastfeeding should not take this prescription pain medication. Women who are pregnant or plan to become pregnant should not take Synalgos-DC, unless the need outweighs the risks. This drug is not approved for children 12 and under. It should especially never be given to children following surgery to remove tonsils or adenoids, because there is a risk of severe respiratory depression or even death. 

In addition, if you have porphyria, a stomach ulcer or a bleeding or blood clotting disorder, you should not take Synalgos-DC. Other conditions that may affect whether this drug is okay for you include:
  • alcohol or drug problems
  • asthma or other breathing problems
  • enlarged prostate or narrow urethra
  • thyroid disorder
  • liver, kidney or gallbladder disease
  • seizures or epilepsy
  • a head injury, brain tumor or any other condition that caused increased pressure inside your skull
  • Addison's disease

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.