What should I avoid while taking Asacol?

 The main drug with a dangerous interaction with Asacol is the Varicella virus vaccine. Alcohol and tobacco use may also affect Asacol's effectiveness. You should be able to follow your normal diet, but your doctor may advise against taking antacids, as these may interfere with how much mesalamine is released into your body. Make sure to talk to your doctor about diet and drug usage while taking Asacol.