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Can Zydone interact with other medications or foods?

Zydone (hydrocodone and acetaminophen), an opioid drug prescribed to treat moderate to moderately severe pain, may interact with other medications and with alcohol.

You should not drink alcohol if you are taking Zydone, because alcohol may worsen the side effects of this drug. Alcohol can also dangerously intensify Zydone's effect on your body.

Because Zydone can interact with a number of drugs, before you take it, you should give your doctor and pharmacist a list of all your other medicines (prescription and nonprescription) and dietary and herbal supplements. Be especially careful to mention if you take the following:

  • any other drug that contains acetaminophen. Combining Zydone with other acetaminophen-containing medicines raises your risk for potentially dangerous liver damage.
  • other opioid (narcotic) medications
  • antihistamines
  • antipsychotic medications
  • drugs to treat anxiety
  • monoamine oxidase (MAO) inhibitors or tricyclic antidepressants
  • sedatives, sleeping pills or tranquilizers
  • medications for irritable bowel syndrome
  • motion sickness medicines
  • the inhaler drug ipratropium
  • antiseizure medications
  • drugs that treat Parkinson's disease
  • anti-ulcer medications
  • medicines for urinary problems
  • blood-thinning medication such as warfarin
  • isoniazid (used to treat tuberculosis)

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.