Can Norco interact with other medications or foods?

The pain medication Norco (hydrocodone and acetaminophen) can interact with other medications, especially those that affect the central nervous system or cause sleepiness—such as other opioid pain medicines, sleeping pills, anti-anxiety drugs, antihistamines, muscle relaxants, tranquilizers or sedatives, barbiturates or antipsychotics. Such drugs may increase the serious side effects of Norco, including slowed heart rate and breathing, and could even lead to coma or death. The same holds true of alcohol, so don't drink while taking Norco. Otherwise you can continue your usual diet; Norco isn't known to interact with foods.

In addition, taking Norco with a tricyclic antidepressant or antidepressant that is a monoamine oxidase inhibitor (MAOI) type may lead to serious side effects. Let your doctor know about all other prescription and over-the-counter drugs you are taking, including vitamins and the herbal supplements kava kava, valerian, St. John's wort and SAMe.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.