Can Synalgos-DC interact with other medications or foods?

Taking the opioid pain reliever Synalgos-DC (dihydrocodeine, aspirin and caffeine) with medicines that affect the central nervous system or cause sleepiness—such as other opioids, sleeping pills, anti-anxiety medicines, antihistamines, muscle relaxants, tranquilizers or sedatives, barbiturates or antipsychotics—may increase serious side effects of Synalgos-DC. The same is true of alcohol, so don't drink while taking Synalgos-DC. The drug doesn't appear to interact with any foods, so you can continue eating your usual diet.

The aspirin in Synalgos-DC can increase the effects of anticoagulant drugs, such as warfarin.

You should not take Synalgos-DC if you're also taking a monoamine oxidase (MAO) inhibitor, a type of drug that's usually prescribed to treat depression, or if you've taken an MAO inhibitor in the last 14 days. Combined, the two drugs can lead to serious, even life-threatening, side effects. MAO inhibitors include phenelzine (Nardil), tranylcypromine (Parnate), isocarboxazid (Marplan) and selegiline (Atapryl and others).

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.