Can Percodan interact with other medications or foods?

Percodan, a combination of the pain relievers oxycodone and aspirin, is not known to interact with any foods, but it can interact with certain medications. Do not take Percodan with cidofovir, probenecid or medicines that treat or prevent blood clots, such as warfarin or heparin.

Other medications that may interact with Percodan include:
  • antihistamines
  • diuretics
  • antidepressants
  • antianxiety drugs
  • pain medications
  • sleep aids
  • muscle relaxants
  • beta-blockers
  • antiseizure medications
  • diabetes medications
  • anti-inflammatory drugs such as ibuprofen
Before you take Percodan, give your doctor a list of your prescription and over-the-counter medicines, as well as any supplements and vitamins you take. Also tell him or her about any illicit drugs you use. Do not drink alcohol while taking Percodan. Mixing alcohol with this medication increases your risk of dangerous side effects.