What are the side effects of Midrin?

Based on information from, a free medication monitoring service, 29% of patients experience side effects while taking Midrin. Some of the side effects reported by iGuard members include drowsiness, restlessness, and vivid dreams. Please follow up with your doctor or other healthcare provider if you are experiencing any symptoms that worsen or do not go away.

The most common side effects of the ingredients in Midrin, isometheptene, dichloralphenazone and acetaminophen are drowsiness, dizziness and decreased alertness or reaction times. This means that you should use caution operating machines or vehicles while you are using this medication. Other non-serious side effects include mild nausea and some changes to your mood.

There are more serious side effects of isometheptene, dichloralphenazone and acetaminophen, about which you should talk to your doctor. These include: severe nausea or stomach pain, fever, flu symptoms like chills or aching, sore throat, increased heart rate or uneven heartbeat, darkened stools or urine, jaundice, excessive weakness and bruising.

If you experience symptoms of allergic reaction to isometheptene, dichloralphenazone and acetaminophen, such as difficulty breathing, hives or swelling in your face and neck, seek immediate emergency medical attention.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.