What should I know about diflunisal before taking it?

Diflunisal can cause stomach bleeding and ulcers, and this risk is higher for people over age 65. You may not want to take diflunisal if you have liver, heart or kidney disease, as it may increase your risk for heart attack or stroke and may reduce your blood's ability to clot. Diflunisal may trigger serious allergic reactions, including anaphylaxis. Call 911 for signs of an allergic reaction including difficulty breathing, swelling of the lips, mouth and tongue.  

When diflunisal is taken with certain other medications, dosages of one or the other may need to be adjusted. You should never take diflunisal with ketorolac or pentoxifylline. Talk to your doctor before using it with acetaminophen (Tylenol), aspirin, anticoagulants, cyclosporine, antacids, hydrochlorothiazide, sulindac and other NSAIDs. Diflunisal may cause Reye's syndrome, a rare but serious illness occurring in children and teens. Diflunisal should not be taken by anyone with a viral infection or chicken pox. Diflunisal may harm an unborn child and should be avoided during pregnancy.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.