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How can I minimize the side effects of Zydone?

To minimize the side effects of the prescription pain medication Zydone (hydrocodone and acetaminophen), you should:
  • Tell your doctor if you have ever had an allergic reaction to any drug, especially Zydone, another opiate drug (such as codeine) or acetaminophen. Do this before you begin taking Zydone.
  • Give your doctor and pharmacist a list of all your other medicines (prescription and nonprescription) and dietary and herbal supplements before you begin taking Zydone. Be sure to mention if you take antidepressants, antihistamines, antianxiety or antipsychotic medications or other narcotic drugs. Once you start taking Zydone, do not take any new drugs or supplements without checking with your doctor or pharmacist first. 
  • Give your doctor a detailed medical history, including current and past medical problems. Be especially careful to mention if you have ever had breathing problems, a head injury, trouble urinating normally, Addison's disease, glaucoma or problems with your lungs, liver, kidneys or thyroid gland.
  • Take Zydone exactly as your doctor tells you to. Do not take more than prescribed or take it more frequently or for a longer period of time than your doctor recommends. 
  • Keep your medical appointments. Your doctor may want to monitor you carefully while you take Zydone.
  • Do not take other medicines that contain acetaminophen. 
  • Do not drink alcohol. 
  • Tell your doctor if you have had surgery in the past or have surgery (including dental surgery) scheduled for the near future. 
  • Avoid becoming pregnant. It's possible that Zydone could harm a developing fetus. 
  • Avoid breastfeeding. It's possible that Zydone could pass into breast milk and potentially harm a nursing infant.
  • Do not drive a car or operate machinery until you know how Zydone affects you. Zydone can cause dizziness and drowsiness and other symptoms.
Call your doctor if you experience any of the following side effects from Zydone and they are severe or persistent:
  • light-headedness
  • dizziness
  • nausea
  • vomiting
  • sleepiness and/or lethargy
  • mental health symptoms such as cloudy thinking, anxiety, fear, feeling uneasy or unwell
  • constipation
  • trouble urinating or urinating completely
  • skin rash or itching
  • blood test abnormalities -- low platelet or white blood cell count
Call your doctor immediately if you have trouble breathing. If you take too much Zydone, call your doctor or 911 immediately, even before you experience any symptoms.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.