How does pentazocine and naloxone interact with other medications and food?

Pentazocine and naloxone interacts with other medications, such as barbiturate anesthetics, cimetidine and sodium oxybate, by making side effects more severe. In addition, pentazocine and naloxone interacts with naltrexone by decreasing the drug's effectiveness. Methadone and narcotic pain medications may not be as effective if you take them with pentazocine and naloxone. Tell your doctor about all medications and supplements that you are taking before you begin taking pentazocine and naloxone.

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