Does Fioricet with Codeine interact with other medications or foods?

Combining the ingredients found in Fioricet with Codeine (butalbital, acetaminophen, caffeine and codeine) with other medications that cause drowsiness may result in dangerous sleepiness. These medications include: over-the-counter cold, allergy and pain-relief medicines: sedatives; narcotic pain medicine; sleeping pills; muscle relaxers; and medicine for seizures, depression or anxiety. Additionally, these other medications may interact adversely with butalbital, acetaminophen, caffeine and codeine phosphate: glycopyrrolate (Robinul), mepenzolate (Cantil), ciprofloxacin (Cipro), atropine (Donnatal), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), scopolamine (Transderm-Scop), bladder or urinary medications, bronchodilators, irritable bowel medications and monoamine oxidase (MAO) inhibitors. Doctors do not recommend drinking alcoholic drinks while on this medication because some of its components may amplify the effects of alcohol.


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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.