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Can I use Vicodin if I am taking a monoamine oxidase inhibitor (MAOI)?

Taking a monoamine oxidase inhibitor (MAOI) along with the prescription pain reliever Vicodin (hydrocodone and acetaminophen) may increase the potency of either medication. Drugs of this type, used mostly to treat depression and anxiety, include:
  • tranylcypromine (Parnate)
  • phenelzine (Nardil)
  • selegiline (Eldepryl) 
  • isocarboxazid (Marplan)
Before you begin using Vicodin, let your doctor know if you take an MAOI.