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Can I use Vicodin if I am taking a monoamine oxidase inhibitor (MAOI)?

Taking a monoamine oxidase inhibitor (MAOI) along with the prescription pain reliever Vicodin (hydrocodone and acetaminophen) may increase the potency of either medication. Drugs of this type, used mostly to treat depression and anxiety, include:
  • tranylcypromine (Parnate)
  • phenelzine (Nardil)
  • selegiline (Eldepryl) 
  • isocarboxazid (Marplan)
Before you begin using Vicodin, let your doctor know if you take an MAOI.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.