Can I use Vicodin if I have a history of liver disease?

Anyone with a history of liver disease, including cirrhosis, should use the prescription pain medication Vicodin (hydrocodone and acetaminophen) with extreme caution. Because it contains acetaminophen, Vicodin comes with a black box warning about potential liver failure and death. People with a history of liver disease are at greater risk for this complication. Don't take Vicodin at a higher dose, or more often, than prescribed. Be sure that you don't get more acetaminophen from other sources -- many over-the-counter medications contain it. Check drug labels (acetaminophen is sometimes listed as "APAP"). If you do use any other medications containing acetaminophen, let your doctor know.