Can I use Tylox if I am taking seizure medications?

If you're taking seizure medications, you should not take Tylox (acetaminophen and oxycodone). Tylox, which is used to treat moderate to moderately severe pain on an as-needed basis, contains oxycodone, an opioid (narcotic) pain reliever. Antiseizure medications such as pregabalin (Lyrica), gabapentin (Neurontin) and lamotrigine (Lamictal) are central nervous system depressants. Taking Tylox with seizure medications can affect your breathing and heart rate.