Can I use Tylox if I have a history of liver disease?

If you have a history of liver disease, your doctor likely will be cautious about prescribing Tylox (acetaminophen and oxycodone) for you. In large quantities, one of the active ingredients in Tylox, acetaminophen, can be toxic to the liver, even in people with normal liver function. In addition, an impaired liver may slow the rate at which the drug is excreted from the body, which could lead to serious side effects from the other active ingredient in Tylox, oxycodone, which is an opioid (narcotic).