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Can Magnacet interact with other medications?

The prescription pain medication Magnacet (oxycodone and acetaminophen) can interact with many other medications. Before you start taking Magnacet, tell your doctor if you're taking any other drugs (prescription or nonprescription) or dietary supplements so he or she can determine if you can safely take Magnacet and at what dose. Be especially sure to tell your doctor if you're taking:
  • a central nervous system (CNS) suppressor. Magnacet contains oxycodone, an opioid that lowers the reactions of your CNS. Because the CNS also controls critical bodily functions like breathing and blood pressure, you could experience serious side effects, including coma and death, if you take Magnacet with another CNS suppressor. Those include other opioid pain medications (such as morphine or OxyContin), phenothiazines (used to treat psychotic disorders and also found in some antihistamines), general anesthetics, some tranquilizers, sedative-hypnotics and antinausea drugs.
  • an agonist/antagonist opioid analgesic. These pain relievers (pentazocine, nalbuphine, buprenorphine, naltrexone and butorphanol) reduce the action of oxycodone, the opioid in Magnacet. If you've been taking Magnacet for a while, starting one of these drugs may cause withdrawal symptoms from Magnacet.
  • a muscle relaxer. These drugs slow down the central nervous system. If taken with Magnacet, they could worsen side effects such as breathing problems and low blood pressure. 
  • an anticholinergic. In combination with Magnacet, these may produce a bowel obstruction. Anticholinergics include ipratropium (Atrovent), oxitropium (Oxivent) and tiotropium (Spiriva).
  • birth control pills. They can decrease Magnacet's effectiveness.
  • loop diuretics, zidovudine, lamotrigine (Lamictal). Magnacet may reduce the effectiveness of these drugs.
  • a beta-blocker (propranolol) or probenecid. These may make Magnacet's effect stronger.
  • an antiseizure medicine, such as carbamazepine, phenobarbitol or phenytoin
  • medicines for fever, coughs and cold
  • the blood thinner warfarin
  • the tuberculosis drug isoniazid

Finally, drinking alcohol can increase Magnacet's potency and cause severe side effects, even death.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.