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What are the plaques and tangles in Alzheimer's disease?

Gayatri Devi, MD
Neurology
The plaques and tangles in Alzheimer's disease are the deposits between and inside nerve cells in the brain that eventually cause death of those cells. In this video, neurologist Gayatri Devi, MD, explains how these deposits progress the condition. 
David A. Merrill, MD
Psychiatry
Plaques and tangles, which are considered the hallmark of the neuropathology of Alzheimer's disease, are the accumulations of proteins. Plaques are extracellular beta-amyloid accumulations of protein. Tangles are inside the neurons -- they are the hyper-phosphorylated filaments of tau proteins.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.