What is a good safety rule when taking acetaminophen?

The daily upper limit for acetaminophen is 4 grams, or 4,000 milligrams (mg). However, it is not recommended that you take that amount routinely or more than 3,000 mg a day. As with most medications, if you are taking acetaminophen daily or routinely need it, please check with your healthcare provider. Acetaminophen is toxic to the liver. If you have other health problems, especially a liver disease, or are taking other medications that may also affect the liver, your daily limit may be lower, so discuss this with your healthcare provider. Other pain medications can contain high amounts of acetaminophen, so this may add to the toxicity as well.
Dr. Mehmet Oz, MD
Cardiology (Cardiovascular Disease)
Never take more than 8 tablets (4,000 mg) of acetaminophen a day. Don't take 4,000 mg in one dose; taking a single large dose can also be dangerous.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.