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What should I know about Mavik before taking it?

Before you take the blood pressure drug Mavik (trandolapril), you should know that doctors are careful about prescribing it to people with certain medical conditions. Before you take it, give your doctor a complete medical history. Make sure to tell him or her if you have ever had heart, liver or kidney disease, lupus, scleroderma or diabetes. Also tell your doctor if you have ever had an allergic reaction to any drug in Mavik's category -- that is, any angiotensin-converting enzyme (ACE) inhibitor.

It's important to know that women who are pregnant should not take Mavik. Drugs in this class may cause birth defects, low levels of amniotic fluid or kidney failure in the developing fetus, and can cause fetal death. Women who are breastfeeding also should not take Mavik, because of the possible risk to a nursing baby.

As an ACE inhibitor, Mavik may cause angioedema, which is swelling under the skin of the lips, eyes, hands, feet or throat. This condition is serious and can even be fatal. ACE inhibitor-induced angioedema is more common among African Americans. (You should also know that ACE inhibitors are less effective among African Americans.)

If you take nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin or ibuprofen, you should know that these drugs can reduce the antihypertensive effect of Mavik. In elderly people and people with reduced kidney function, this drug combination can cause kidney failure.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.