What should I know about Aceon before taking it?

Aceon (perindopril) is most commonly prescribed to treat high blood pressure. It belongs to a class of drugs called angiotensin-converting enzyme (ACE) inhibitors, which help block the production of chemicals that constrict blood vessels, so that blood can flow more smoothly. Aceon is also sometimes given to people who have heart failure and to people with coronary artery disease to prevent heart attack.

Certain people shouldn't take Aceon, including women who are pregnant and anyone who's had a previous allergic reaction to Aceon or another ACE inhibitor, or who have a history of angioedema, a condition characterized by swelling of the face, eyes, lips, tongue, legs and feet, as well as hoarseness or trouble swallowing or breathing. Angioedema is a hallmark of anaphylaxis, a deadly allergic reaction. If you experience angioedema stop taking Aceon and get medical help immediately.

Aceon has a number of potential side effects. The most common are dry cough, headache, weakness, dizziness, diarrhea, upset stomach, abdominal pain or back pain. Let your doctor know if any of these are extreme or long-lasting. You should also call your doctor right away if you develop any of these serious (but rare) side effects:
  • fever, sore throat and chills
  • irregular or rapid heartbeat
ACE inhibitors like Aceon have been linked to kidney failure in susceptible people, such as those with severe heart failure or renal artery stenosis (constriction of the artery leading to the kidney). People with kidney or liver disease must be monitored carefully while on Aceon or another ACE inhibitor.

Sometimes Aceon can cause blood pressure to dip too low (hypotension). Symptoms include feeling lightheaded or dizzy or fainting. This side effect is most likely to occur in people who also take a diuretic, follow a low-salt diet, are undergoing dialysis or have diarrhea or vomiting. Often, it can be corrected with a change in dose.

Be aware that Aceon interacts with other medications (prescription and nonprescription) and dietary supplements, so make sure your doctor knows about everything you're taking. If you're on any of the following types of medications, he or she will monitor you carefully:
  • water pills (diuretics)
  • NSAIDs (non-steroidal anti-inflammatory agents), including the pain medications ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn) and celecoxib (Celebrex)
  • potassium supplements
  • injectable gold (sodium aurothiomalate)
  • lithium

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.