If you are pregnant or breastfeeding, do not take lisinopril-hydrochlorothiazide (HCTZ). If you are allergic to lisinopril, hydrochlorothiazide or any of the other ingredients of this drug, do not take lisinopril-HCTZ. If you are allergic to sulfa drugs, do not take lisinopril-HCTZ. If you have kidney problems, liver problems or a history of angioedema, lisinopril-HCTZ may not be the best choice for you. Lisinopril-HCTZ is not used to treat children.