How does lisinopril and hydrochlorothiazide interact with other drugs?

If you take lisinopril-hydrochlorothiazide (HCTZ) with a muscle relaxant, you may experience increased relaxant levels in the blood. If you take lisinopril-HCTZ with nonsteroidal anti-inflammatory drugs (NSAIDs), there is an increased risk of kidney damage and a decrease of lisinopril-HCTZ's effectiveness. Using lisinopril-HCTZ with potassium supplements or potassium-sparing diuretics can lead to dangerously high levels of potassium in the blood. Using lisinopril-HCTZ with lithium can increase lithium levels in the blood. Taking it with diuretics can lead to dangerously low blood pressure. This drug can also cause dangerous drops in blood pressure when used with barbiturates and narcotics.

If you are taking insulin or oral diabetes medications, lisinopril HCTZ can increase your risk of high blood sugar levels. People with diabetes who are taking aliskiren to lower blood pressure should not take lisinopril HCTZ. It can interact with liquid gold therapy, causing drops in blood pressure, flushing, vomiting and nausea. Using lisinopril-HCTZ at the same time as colestipol, norepinephrine or cholestyramine can decrease lisinopril and HCTZ's effectiveness. Taking lisinopril-HCTZ at the same time as corticosteroids or corticotropin can lead to electrolyte imbalance. It can interact with alcohol, causing dangerous drops in blood pressure. Provide your doctor and pharmacist with a complete list of prescription and over-the-counter drugs, supplements and herbals that you are taking, before starting lisinopril-HCTZ.

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