Is there a drug interaction between non-steroidal Oxycodone and Accupril?

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Non-steroidal anti-inflammatory medications can reduce the effectiveness of ACE inhibitors such as Accupril. In general, if you are using an NSAID for more than a week, and are experiencing pain (that, in itself, can contribute to your blood pressure increase), it makes sense to monitor your blood pressure (and Accupril dose) more carefully and please follow up with your doctor to discuss your concerns.