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Can Zestril interact with other medications or foods?

Zestril (lisinopril) can interact with many other medications, so before you start taking it, tell your doctor about all your other drugs (prescription and over-the-counter) as well as dietary or herbal supplements. Your doctor may also have some instructions about your diet when you start this drug, which treats high blood pressure and certain heart problems.

Some of the drugs that can interact with Zestril include:
  • certain other blood pressure drugs, which can enhance Zestril's effect and make you dizzy
  • nonsteroidal anti-inflammatory drugs (NSAIDs), which in combination with Zestril may worsen kidney function in elderly people. Taking these drugs together may also be a problem for people who already have poor kidney function. In addition, NSAIDs may reduce Zestril's blood-pressure-lowering effects. 
  • certain diabetes medicines, which may lower your blood sugar too much if you take them with Zestril
  • lithium for bipolar disorder, which can rise to dangerous levels in your blood if you take Zestril while you're on it. Your doctor will monitor you closely if you take this combination.
If you're on Zestril, talk to your doctor before you use salt substitutes containing potassium. The combination may lead to abnormally high potassium levels in the blood, which can cause dangerous heart arrhythmia.

Your doctor may put you on a low-salt diet while you're on Zestril. If so, follow it carefully.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.