Can Prinivil interact with other medications or foods?

Prinivil (lisinopril) doesn't interact with foods, but drinking alcohol while taking Prinivil can increase the risk for side effects such as dizziness and drowsiness. This drug, which is used to treat high blood pressure and congestive heart failure and to increase survival odds after a heart attack, also can interact with other medications and supplements, including salt substitutes, potassium supplements, medications containing potassium or ones that affect potassium levels such as heparin. The combination can increase potassium in the blood, a condition known as hyperkalemia, and cause dangerous side effects.

Prinivil can interact with nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, indomethacin or COX-2 inhibitors (celecoxib, rofecoxib). Taking Prinivil with an NSAID can make it less effective. If you have kidney problems, taking these two medications together could worsen your condition and even lead to kidney failure. Prinivil can also interact with diuretics (water pills), causing blood pressure to drop too low.

Do not take Prinivil along with certain diabetes medications such as insulin and oral drugs, which can cause hypoglycemia (low blood sugar). Other drugs that may interact with Prinivil include lithium, aspirin, injectable gold (sodium aurothiomalate), azathioprine, aliskiren, clozapine, ephedra, entecavir, pregabalin, other angiotensin converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARB) and monoamine oxidase inhibitors (MAOIs). The supplement hawthorn may interact with Prinivil as well, causing blood pressure to drop too low. It is critical to tell your doctor about all prescription and over-the-counter medications, supplements and vitamins you take before starting on Prinivil.

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