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Can Accupril interact with other medications?

The blood pressure medication Accupril (quinapril) can interact with the following substances:
  • diuretics (water pills). Many people take a water pill along with Accupril to control blood pressure. If you take both, your doctor will probably monitor you closely because your blood pressure may drop too low at first. In some cases, this can be prevented by stopping the diuretic or lowering the dose, taking a lower dose of Accupril or increasing the salt in your diet before beginning treatment with Accupril.
  • potassium. If you take Accupril along with potassium supplements or certain other drugs, your blood potassium level may become too high, putting you at risk for potentially deadly heart problems. These medications include spironolactone, amiloride, triamterene and heparin. If you’re taking any of these drugs in combination with Accupril your doctor should frequently check your potassium level. People with kidney disease or diabetes are at added risk of developing this problem.
  • gold. In rare cases, people treated with both injectable gold (sodium aurothiomalate) and ACE inhibitors like Accupril have experienced side effects that include facial flushing, nausea, vomiting and hypotension.
  • lithium. The risk of lithium overdose is very high in people taking ACE inhibitors, so this combination is generally avoided. People who also take a diuretic may be at added risk. If you use both Accupril and lithium your doctor should monitor your blood level of lithium frequently.
  • nonsteroidal anti-inflammatory drugs (NSAIDs). Taking Accupril along with an NSAID can interfere with Accupril's ability to control blood pressure and also impair kidney function to the point of kidney failure. NSAIDs include the pain medications ibuprofen, naproxen, indomethacin and celecoxib. The elderly, people who already have a kidney condition and those taking a diuretic (or whose fluid levels are otherwise low) are at increased risk. Be sure your doctor knows if you’re taking both an NSAID and Accupril because he or she should monitor you carefully.
  • anesthesia. Some forms of surgical anesthesia cause blood pressure to drop. In combination with Accupril, they could cause your pressure to become too low. If you must have surgery while on Accupril, make sure your surgeon and anesthesiologist are aware that you take Accupril before you get anesthesia.
  • aliskiren. People who have diabetes or kidney disease should not take Accupril along with the blood pressure drug aliskiren.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.