Who should not take HRT?

Women who have had a blood clot in the leg or in the lung (venous thrombosis or pulmonary embolism) within the past six months should not take hormone replacement therapy (HRT) because estrogen can increase blood clotting. Additionally, women undergoing active treatment for breast, ovarian, or uterine cancer should not take estrogen-containing hormones unless they are prescribed by an oncologist because estrogen replacement therapy (ERT) can stimulate the growth of some tumors.

Also, women with a history of gallbladder disease, severe migraine headaches, or a strong family history of either gallstones or female cancers (e.g., breast, ovarian, or uterine) should not take HRT because it may increase the risk of developing these conditions.

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